The frequency of handwashing and disinfection has increased during the coronavirus disease 2019 (COVID-19) pandemic, 1 as it is believed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can also be transmitted by direct and indirect contact. Conclusionĭaily hand hygiene with ABHS showed the lowest rates of skin barrier disruption and the highest reduction of CFU. Disinfectant wipes were considered more difficult to use ( P = .013) compared with water and soap and ABHS. Bacteria and fungi colony-forming unit (CFU) count reductions were lower for the water and soap group than for ABHS and disinfectant wipes. After the 8-hour shift, TEWL increase was higher with disinfectant wipes than with soaps or ABHS (+5.45 vs +3.87 vs −1.46 g h −1 m −2, respectively P = .023). Sixty-two participants were included and 20, 21, and 21 were randomized to use water and soap, ABHS, and disinfectant wipes, respectively. Tolerance and acceptability of each product were recorded after work. Epidermal barrier functional parameters, such as transepidermal water loss (TEWL), and the microbial load were assessed before and immediately after the working day. Participants were randomized to sanitize their hands with water and soap, alcohol-based hand sanitizers (ABHSs), or disinfectant wipes during their 8-hour working shift. MethodsĪ randomized controlled clinical trial was conducted. To compare the impact on skin barrier function of different hand hygiene measures in healthcare workers in daily practice. There is scarce evidence regarding the impact of different hand hygiene procedures on skin barrier function in clinical practice. Coronavirus disease 2019 (COVID-19) has increased the frequency of handwashing.
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